Brown algae from Australia Insist on manual harvesting

Just to give you the best quality!

Adhering to the principles of integrity and honesty, and rigorous raw material quality requirements, we choose to extract FA1 brown fructose from the "Organic production of Fucus" from the clean waters of Australia-Tasmania. Brown algae is the larger species of seaweed. The appearance is from dark brown to olive green. The cell wall is rich in viscous algae, which can protect the seaweed from damage and keep it moist. Most of the brown algae are distributed in the intertidal zone of the rocky shore with low temperature, forming the wonders of the marine forest. Purely hand-harvested, harvesting mature and healthy brown algae to maintain the sea environment and brown algae ecology, and sustainable development with the earth in an environmentally friendly way.

Exclusive cold water Extraction technology

Raw material organic certification!

Generally use solvent and high temperature extraction, easy to break the chain to cause hydrolysis,The vulnerable structure is ineffective.

Exclusive use of MEDBRING Cold water extraction technology can completely retain the original activity and polysaccharide structure.No residual organic solvent and degradation of fucoidan.

Top team R&D and manufacturing

Technology is unique worldwide!

MEDBRING has a top R&D team and laboratory.Enjoy unique global R&D and production capabilities, leading Development of high purity extraction of FA brown fructose in the worldUse and production.

%

We promise!

Ultra high purity quality assurance

The purity of FA1 brown glycogen is the key to health care!

Highest quality of the brown glycogen is preferred.

Just to give you the best quality!

HIGH-PURITY FUCOIDAN EXTRACT

Organic Seaweeds extract

Source：Global high quality brown algae, hand harvested

Purity：90% high purity

Extraction Technology：Maritech Exclusive Cold Water Extraction

Structural activity：Intact activity and polysaccharide structure

Content per tablet：1000mg high dose without added

Raw material certification：Australian ACO organic certification

Health effects：High health (excellent)

HIGH-PURITY FUCOIDAN EXTRACT

Natural extraction. Six product advantages

MEDBRING-FA褐醣原素驚人的六大產品優勢

抗腫瘤 Anticancer—— 引用文獻列表

Cancer cell inhibition 抑制腫瘤細胞

(1) 誘導癌細胞凋亡
褐藻醣膠透過調節內質網壓力級聯反應，減弱癌細胞存活並促進癌細胞凋亡，達到抗腫瘤的效果。

Chen S, Zhao Y, Zhang Y, Zhang D. Fucoidan induces cancer cell apoptosis by modulating the endoplasmic reticulum stress cascades. PLoS One. 2014;9(9):e108157.

(2) 與化學治療產生協同作用
褐藻醣膠與化療藥物-順鉑、諾瓦得士、汰癌勝，共同針對乳癌細胞來調控其細胞週期及ERK/Akt細胞訊息傳遞路徑，抑制癌細胞生長；另外，經由增加乳癌細胞內氧化壓力與調降Bcl-xL/Mcl-1抗凋亡蛋白的表現量，促進癌細胞凋亡。褐藻醣膠和化療藥物有效產生協同作用，發揮抗癌功效。

Zhang Z, Teruya K, Yoshida T, Eto H, Shirahata S. Fucoidan extract enhances the anti-cancer activity of chemotherapeutic agents in MDA-MB-231 and MCF-7 breast cancer cells. Mar Drugs. 2013;11(1):81-98.

(3) 誘導前列腺癌細胞凋亡
褐藻醣膠經由活化ERK1/2 MAPK及去活化p38 MAPK/PI3K/Akt細胞訊息傳遞路徑，誘導人類前列腺癌細胞(PC-3細胞)走向內在與外在細胞凋亡途徑，最終引發癌細胞凋亡。

Boo HJ, Hong JY, Kim SC, Kang JI, Kim MK, Kim EJ, Hyun JW, Koh YS, Yoo ES, Kwon JM, Kang HK. The anticancer effect of fucoidan in PC-3 prostate cancer cells. Mar Drugs. 2013;11(8):2982-99.

(4) 誘導乳癌細胞凋亡
褐藻醣膠會誘導半胱天冬酶-8(Caspase-8)聚集到MCF-7乳癌細胞內β1-整合素(β1-integrin)結構區域，與β1-整合素結合後被活化，啟動Caspase級聯反應，導致癌細胞凋亡。

Yamasaki Y, Yamasaki M, Tachibana H, Yamada K. Important role of β1-integrin in fucoidan-induced apoptosis via caspase-8 activation. Biosci Biotechnol Biochem. 2012;76(6):1163-8.

Reduction of tumour growth 減緩腫瘤生長

抑制癌細胞淋巴管新生
褐藻醣膠藉由調降血管內皮生長因子受體3(VEGFR3)及同源異形盒蛋白1(PROX1)的表達，抑制NF-κB/PI3K/Akt細胞訊息傳遞途徑，進而阻斷癌細胞淋巴管新生，並預防癌細胞經淋巴轉移。

Yang Y, Gao Z, Ma Y, Teng H, Liu Z, Wei H, Lu Y, Cheng X, Hou L, Zou X. Fucoidan inhibits lymphangiogenesis by downregulating the expression of VEGFR3 and PROX1 in human lymphatic endothelial cells. Oncotarget. 2016;7(25):38025-35.

MEDBRING-FA褐醣原素驚人的六大產品優勢

維護腸胃道健康 Digestive health—— 引用文獻列表

Anti-pathogenic qualities 抗病原性

與抗生素產生協同作用
褐藻醣膠具有抗菌特性，與抗生素-安比西林及見大黴素產生協同作用，抑制細菌細胞壁的合成，有效抵抗口腔致病菌。

Lee KY, Jeong MR, Choi SM, Na SS, Cha JD. Synergistic effect of fucoidan with antibiotics against oral pathogenic bacteria. Arch Oral Biol. 2013;58(5):482-92.

The stomach: Helicobacter pylori 胃：胃幽門螺旋桿菌

(1) 預防胃潰瘍
褐藻醣膠透過調控促發炎細胞激素，避免它對胃黏膜產生氧化損傷，有效預防胃潰瘍。

Choi JI, Raghavendran HR, Sung NY, Kim JH, Chun BS, Ahn DH, Choi HS, Kang KW, Lee JW. Effect of fucoidan on aspirin-induced stomach ulceration in rats. Chem Biol Interact. 2010;183(1):249-54.

(2) 輔助治療胃潰瘍
褐藻醣膠會誘導胃部上皮細胞分泌鹼性纖維母細胞生長因子(bFGF)及表皮生長因子(EGF)，以促進胃部細胞增殖，達到修復傷口，治癒胃潰瘍之目的。

Mohammad J, Ina R, Wahyu D, Ali D, A. Ariani, Harjono A. The Efficacy of Fucoidan on Gastric Ulcer. IJBiotech. 2006;11(2):908-13.

The upper and lower intestine: Colitis上下結腸：結腸炎

調控促發炎細胞激素，改善急性結腸炎
褐藻醣膠具有抗發炎功能，可抑制促發炎細胞激素產生，緩解結腸炎症狀*，有效改善急性結腸炎
*結腸炎症狀：腹痛、腹瀉、便血及體重減輕

Lean QY, Eri RD, Fitton JH, Patel RP, Gueven N. Fucoidan Extracts Ameliorate Acute Colitis. PLoS One. 2015;10(6):e0128453.

The liver 肝

避免酒精性肝損傷
褐藻醣膠可調節小鼠肝臟及人類肝癌HepG2細胞中的發炎介質，預防酒精性肝損傷。褐藻醣膠藉由降低血液中天冬氨酸轉胺酶(AST)與丙氨酸轉胺脢(ALT)、抑制轉化生長因子β1(TGF-β1)表達、減少環氧化酶-2(COX-2)和一氧化氮(NO)產生，並且增加血鐵質氧化酶-１(HO-1)表達，來發揮其抗發炎及抗纖維化作用，具有降低酒精性肝損傷風險的功效
*血液中天冬氨酸轉胺酶(AST)、丙氨酸轉胺脢(ALT)是肝細胞製造最多的酵素，常用來評估肝臟發炎或受損程度
*轉化生長因子β1(TGF-β1)為肝臟纖維化誘導因子
*環氧化酶-2(COX-2)、一氧化氮(NO)會促進發炎反應
*血鐵質氧化酶-１(HO-1)是抗氧化劑，能抑制肝臟發炎介質

Lim JD, Lee SR, Kim T, Jang SA, Kang SC, Koo HJ, Sohn E, Bak JP, Namkoong S, Kim HK, Song IS, Kim N, Sohn EH, Han J. Fucoidan from Fucus vesiculosus protects against alcohol-induced liver damage by modulating inflammatory mediators in mice and HepG2 cells. Mar Drugs. 2015;13(2):1051-67.

MEDBRING-FA褐醣原素驚人的六大產品優勢

免疫調節作用Immune modulation—— 引用文獻列表

Anti-pathogenic qualities 抗病原性

(1) 降低第一型人類嗜T淋巴球病毒(HTLV-1)的病毒量
褐藻醣膠透過阻斷HTLV-1病毒於宿主細胞之間的傳遞，降低病毒量，有效避免感染宿主細胞，進而預防HTLV-1相關疾病*
*HTLV-1相關疾病有兩類：熱帶痙攣性痲痺/HTLV關聯性脊髓病(HAM/TSP)、成人T細胞性白血病(ATL)

Araya N, Takahashi K, Sato T, Nakamura T, Sawa C, Hasegawa D, Ando H, Aratani S, Yagishita N, Fujii R, Oka H, Nishioka K, Nakajima T, Mori N, Yamano Y. Fucoidan therapy decreases the proviral load in patients with human T-lymphotropic virus type-1-associated neurological disease. Antivir Ther. 2011;16(1):89-98.

(2) 預防C型肝炎病毒感染
褐藻醣膠經由抑制C型肝炎病毒在宿主體內增殖，並刺激宿主的先天性與後天性免疫反應，以降低感染C型肝炎的風險

Mori N, Nakasone K, Tomimori K, Ishikawa C. Beneficial effects of fucoidan in patients with chronic hepatitis C virus infection. World J Gastroenterol. 2012;18(18):2225-30.

Damping allergic responses 抑制過敏反應

調控IgE的產生，預防過敏反應
褐藻醣膠藉由抑制IL-4及抗CD40抗體，以降低它對異位性皮膚炎患者其人外周血單核細胞(human PBMC)刺激，進而減少IgE的製造，另外還會抑制B細胞中的Cε生殖系轉錄本，並且降低IgE分泌細胞的數量，來抑制人外周血單核細胞產生IgE，達到抗過敏之效用。

Iwamoto K, Hiragun T, Takahagi S, Yanase Y, Morioke S, Mihara S, Kameyoshi Y, Hide M. Fucoidan suppresses IgE production in peripheral blood mononuclear cells from patients with atopic dermatitis. Arch Dermatol Res. 2011;303(6):425-31.

4-3 Boosting immune responses 強化免疫反應

輔助增進樹突細胞成熟，促進啟動細胞性免疫反應
褐藻醣膠會刺激樹突細胞成熟，並利用其抗原呈現特性來幫助辨識抗原，有效活化第一型輔助型T細胞及毒殺型T細胞，引發細胞性免疫反應。

Jin JO, Zhang W, Du JY, Wong KW, Oda T, Yu Q. Fucoidan can function as an adjuvant in vivo to enhance dendritic cell maturation and function and promote antigen-specific T cell immune responses. PLoS One. 2014;9(6):e99396.

Precision medical functional supplements.

MEDBRING adheres to

the principle of professional responsibility and to uses the exclusive patented extraction from natural sources in the selection of ingredients to ensure the efficacy of the products.

Integrate the precision

only select the process with international GMP, HACCP, ISO certification laboratories of health food factories, and the production process is strictly monitored to ensure product quality.

Established

teams of a multi-national professional physician, nutritionist, pharmacist R&D laboratory to lead the development and production of high-quality functional medical supplements in the world.

Insist on the use

of ingredients that have obtained internationally relevant certifications, and the original suppliers have repeatedly tested in the laboratory or clinical to ensure that the source of ingredients is absolutely free from pollution.

Safe and secure!

The functional medical supplements series had passed a number of organic and related food certifications.

Australian
Certified Organic

Halal
Certification

Kosher Meat
Certification

ISO
9001:2000

HACCP

Quality meets the three highest international standards of FDA, EP, TGA.

(FDA Food and Drug Administration)｜(EP EU)｜ (TGA Australian Drug Administration)

HIGH-PURITY

FUCOIDAN EXTRACT

Organic Seaweeds extract

Amazing health effects

You can't help but know!

Industry's only

90% Ultra high purity Organic Fucoidan

The health value of FA brown fructose-Fucoidan is well known in addition to the effects of regulating physiological functions and enhancing physical strength. With the development of science, scholars from various circles have also confirmed that brown sugar has many health benefits for health.

Organic Fucoidan Eight effects

Brown algae from Australia Insist on manual harvesting

Exclusive cold water Extraction technology

Generally use solvent and high temperature extraction, easy to break the chain to cause hydrolysis,The vulnerable structure is ineffective.

Exclusive use of MEDBRING Cold water extraction technology can completely retain the original activity and polysaccharide structure.No residual organic solvent and degradation of fucoidan.

Top team R&D and manufacturing

MEDBRING has a top R&D team and laboratory.Enjoy unique global R&D and production capabilities, leading Development of high purity extraction of FA brown fructose in the worldUse and production.

%

We promise!

Ultra high purity quality assurance

The purity of FA1 brown glycogen is the key to health care!

Highest quality of the brown glycogen is preferred.

Just to give you the best quality!

HIGH-PURITY FUCOIDAN EXTRACT

Organic Seaweeds extract

Source：Global high quality brown algae, hand harvested

Purity：90% high purity

Extraction Technology：Maritech Exclusive Cold Water Extraction

Structural activity：Intact activity and polysaccharide structure

Content per tablet：1000mg high dose without added

Raw material certification：Australian ACO organic certification

Health effects：High health (excellent)

HIGH-PURITY FUCOIDAN EXTRACT

Natural extraction. Six product advantages

抗腫瘤 Anticancer—— 引用文獻列表

輔助抑制發炎反應 Anti-inflammatory—— 引用文獻列表

維護腸胃道健康 Digestive health—— 引用文獻列表

免疫調節作用Immune modulation—— 引用文獻列表

心血管健康 Cardiovascular health—— 引用文獻列表

強化神經保護 Neuroprotection—— 引用文獻列表

Precision medical functional supplements.

MEDBRING adheres to

the principle of professional responsibility and to uses the exclusive patented extraction from natural sources in the selection of ingredients to ensure the efficacy of the products.

Integrate the precision

only select the process with international GMP, HACCP, ISO certification laboratories of health food factories, and the production process is strictly monitored to ensure product quality.

Established

teams of a multi-national professional physician, nutritionist, pharmacist R&D laboratory to lead the development and production of high-quality functional medical supplements in the world.

Insist on the use

of ingredients that have obtained internationally relevant certifications, and the original suppliers have repeatedly tested in the laboratory or clinical to ensure that the source of ingredients is absolutely free from pollution.

Safe and secure!

The functional medical supplements series had passed a number of organic and related food certifications.

Quality meets the three highest international standards of FDA, EP, TGA.

Adheres to the profession. Pursuit of quality.

Rigorous attitude worthy of your trust!

Precision health supplements

Tailored health solutions

Contact us