BDNF (Brain-derived neurotrophic factor) is a protein in the human brain, produced by brain-derived neurotrophic factor genes. Brain-derived neurotrophic factor is a kind of neurotrophic factor, which exists in the human nervous system. BDNF is the most abundant neurotrophic factor in the brain. In addition to regulating the growth and survival of neurons (nerve cells) and promoting the formation of synapses of brain nerve cells, it can also regulate neurotransmitters and intracellular messages. Transmission has a very diverse and important function in the central nervous system. Simply put, it is an active protein that exists in the central nervous system (CNS) and the peripheral nervous system (PNS). It is a very important and essential nutrient protein for the brain.

Studies have shown that the hippocampal gyrus, which controls memory in the brain, is particularly rich in BDNF, which is also very important for the growth of synapses and long-term memory. In 2004, a study published in the international authoritative journal "Science" solved the mystery of long-term memory, pointing out that BDNF is a key protein in the formation of long-term memory, and another enzyme system called tPA/plasmin is the production of active BDNF The decisive factor; there have been many international studies showing that the lack of BDNF may cause cognitive dysfunction, such as Alzheimer’s disease, which is one of the common degenerative dementias. In addition, long-term stress or depression may also inhibit the secretion of BDNF in the brain, affect memory and cognitive functions, and even cause more serious problems such as autonomic nervous system disorders or hippocampal atrophy.

BDNF gene - brain derived neurotrophic factor

The normal function BDNF gene provides instructions for making a protein found in the brain and spinal cord called brain-derived neurotrophic factor. This protein promotes the survival of nerve cells (neurons) by playing a role in the growth, maturation (differentiation), and maintenance of these cells. In the brain, the BDNF protein is active at the connections between nerve cells (synapses), where cell-to-cell communication occurs. The synapses can change and adapt over time in response to experience, a characteristic called synaptic plasticity. The BDNF protein helps regulate synaptic plasticity, which is important for learning and memory.

The BDNF protein is found in regions of the brain that control eating, drinking, and body weight; the protein likely contributes to the management of these functions.

Studies have shown that the concentration of BDNF can be increased by specific dietary supplements, and exercise can also promote the secretion of BDNF in the brain, which has a positive effect on the growth of brain neurons (nerve cells) and improves synaptic plasticity. Can improve memory and cognitive function.